- 1854
- Ashmun Institute, the first school of higher learning for young black men, founded by John Miller Dickey and his wife, Sarah Emlen Cresson; later (1866) renamed Lincoln University (Pa.) after President Abraham Lincoln.
- 1856
- Wilberforce University, the first black school of higher learning owned and operated by African Americans, founded by the African Methodist Episcopal Church. Its president, Daniel A. Payne, became the first African American University president in the country.
- 1869
- Howard University's law school becomes the country's first black law school.
- 1876
- Meharry Medical College, the first black medical school in the U.S., founded by the Freedman's Aid Society of the Methodist Episcopal Church.
- 1881
- Spelman College, the first college for black women in the U.S., founded by Sophia B. Packard and Harriet E. Giles.
- 1881
- Booker T. Washington founds the Tuskegee Normal and Industrial Institute in Alabama. The school became one of the leading schools of higher learning for African Americans, and stressed the practical application of knowledge. In 1896, George Washington Carver began teaching there as director of the department of agricultural research, gaining an international reputation for his agricultural advances.
- 1922
- William Leo Hansberry teaches the first course in African civilization at an American university, at Howard University.
- 1944
- Frederick Douglass Patterson establishes the United Negro College Fund to help support black colleges and black students.

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